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Creative Diagnostics

Company Summary:

  • Since 2005
  • 401-500 Employees
  • Turnover 1,750,000.00 USD per year
  • Corporation

Additional Contacts:

http://www.creative-diagnostics.com
Export Department
Lily Green
Phone: +1 - 631 - 624-4882/+1 -
Fax: +1 - 631 - 614-7828

Company Address:

45-16 Ramsey Road Shirley
New York, New York
United States, 11967
Web Page Link: http://www.toboc.com/creativediagnostics

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Details of Product or Sell Offer
product

Mouse Anti-Human BTK Monoclonal Antibody

"Mouse Anti-Human BTK Monoclonal Antibody" is listed under  Other - Pharmaceutical ChemicalsCategory

Bruton quots tyrosine kinase (or Btk) is a type of kinase enzyme implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (XLA). Its exact mechanism of action remains unknown, but it plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The BTK gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified. Btk contains a PH domain which binds Phosphatidylinositol -trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messagers, inositol triphosphate (IP3) and diacylglycerol(DAG), which then go on to modulate thBruton quots tyrosine kinase (or Btk) is a type of kinase enzyme implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (XLA). Its exact mechanism of action remains unknown, but it plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The BTK gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified. Btk contains a PH domain which binds Phosphatidylinositol -trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messagers, inositol triphosphate (IP3) and diacylglycerol(DAG), which then go on to modulate the activity of downstream proteins during B-cell signaling.e activity of downstream proteins during B-cell signaling.....



Product Detail

NA
5     USD Per Milligram(s)
1     Milligram(s)
3   day(s)
1   Milligram(s) Daily
antibody, CAB-058MH
#antibody, #CAB-058MH

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